1aok: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1aok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aok OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1aok RCSB], [http://www.ebi.ac.uk/pdbsum/1aok PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1aok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aok OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1aok RCSB], [http://www.ebi.ac.uk/pdbsum/1aok PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/PA2I_VIPAE PA2I_VIPAE]] Heterodimer: postsynaptic neurotoxin.<ref>PMID:23554559</ref> Monomer: Acidic phospholipase A2 homolog that is non-toxic.<ref>PMID:23554559</ref> [[http://www.uniprot.org/uniprot/PA21B_VIPAE PA21B_VIPAE]] Heterodimer: postsynaptic neurotoxin.<ref>PMID:23554559</ref> <ref>PMID:24678250</ref> Monomer: snake venom phospholipase A2 (PLA2) that shows hemolytic activity and inhibition of platelet aggregation. The hemolytic activity occurs only in presence of fatty acids (unsaturated fatty acids facilitate induce a strong hemolytic activity, whereas saturated fatty acids induce a slight activity). The inhibition of platelet aggregation is almost maximal when aggregation is induced by collagen, and arachidonic acid, whereas it is only of 30% when the aggregation is induced by ADP. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:23554559</ref> <ref>PMID:24678250</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
