1yo8: Difference between revisions
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[[Image:1yo8.gif|left|200px]] | [[Image:1yo8.gif|left|200px]] | ||
'''Strucuture of the C-terminal domain of human thrombospondin-2''' | {{Structure | ||
|PDB= 1yo8 |SIZE=350|CAPTION= <scene name='initialview01'>1yo8</scene>, resolution 2.60Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> and <scene name='pdbligand=CA:CALCIUM ION'>CA</scene> | |||
|ACTIVITY= | |||
|GENE= THBS2, TSP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |||
}} | |||
'''Strucuture of the C-terminal domain of human thrombospondin-2''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1YO8 is a [ | 1YO8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YO8 OCA]. | ||
==Reference== | ==Reference== | ||
Structure of the calcium-rich signature domain of human thrombospondin-2., Carlson CB, Bernstein DA, Annis DS, Misenheimer TM, Hannah BL, Mosher DF, Keck JL, Nat Struct Mol Biol. 2005 Oct;12(10):910-4. Epub 2005 Sep 25. PMID:[http:// | Structure of the calcium-rich signature domain of human thrombospondin-2., Carlson CB, Bernstein DA, Annis DS, Misenheimer TM, Hannah BL, Mosher DF, Keck JL, Nat Struct Mol Biol. 2005 Oct;12(10):910-4. Epub 2005 Sep 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16186819 16186819] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: egf; ca(2+)-binding domains; lectin domain; disulfide]] | [[Category: egf; ca(2+)-binding domains; lectin domain; disulfide]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:25:24 2008'' | ||
Revision as of 13:25, 20 March 2008
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| 1yo8, resolution 2.60Å | |||||||||||||
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| Ligands: | NAG and CA | ||||||||||||
| Gene: | THBS2, TSP2 (Homo sapiens) | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Strucuture of the C-terminal domain of human thrombospondin-2
Overview
Thrombospondins (THBSs) are secreted glycoproteins that have key roles in interactions between cells and the extracellular matrix. Here, we describe the 2.6-A-resolution crystal structure of the glycosylated signature domain of human THBS2, which includes three epidermal growth factor-like modules, 13 aspartate-rich repeats and a lectin-like module. These elements interact extensively to form three structural regions termed the stalk, wire and globe. The THBS2 signature domain is stabilized by these interactions and by a network of 30 bound Ca(2+) ions and 18 disulfide bonds. The structure suggests how genetic alterations of THBSs result in disease.
About this Structure
1YO8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the calcium-rich signature domain of human thrombospondin-2., Carlson CB, Bernstein DA, Annis DS, Misenheimer TM, Hannah BL, Mosher DF, Keck JL, Nat Struct Mol Biol. 2005 Oct;12(10):910-4. Epub 2005 Sep 25. PMID:16186819
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