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{{STRUCTURE_4hvn|  PDB=4hvn  |  SCENE=  }}
==Crystal structure of hypothetical protein with ketosteroid isomerase-like protein fold from Catenulispora acidiphila DSM 44928 in complex with Trimethylamine.==
===Crystal structure of hypothetical protein with ketosteroid isomerase-like protein fold from Catenulispora acidiphila DSM 44928 in complex with Trimethylamine.===
<StructureSection load='4hvn' size='340' side='right' caption='[[4hvn]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
{{ABSTRACT_PUBMED_24562475}}
== Structural highlights ==
<table><tr><td colspan='2'>[[4hvn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Catad Catad]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HVN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HVN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KEN:N,N-DIMETHYLMETHANAMINE'>KEN</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4h3u|4h3u]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Caci_0382 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=479433 CATAD])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hvn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hvn RCSB], [http://www.ebi.ac.uk/pdbsum/4hvn PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Catenulispora acidiphila is a newly identified lineage of actinomycetes that produces antimicrobial activities and represents a promising source of novel antibiotics and secondary metabolites. Among the discovered protein coding genes, 68 % were assigned a putative function, while the remaining 32 % are genes encoding "hypothetical" proteins. Caci_0382 is one of the "hypothetical" proteins that has very few homologs. Sequence analysis shows that the protein belongs to the NTF2-like protein family. The structure of Caci_0382 demonstrates that it shares the same fold and has a similar active site as limonene-1,2-epoxide hydrolase, which suggests that it may have a related function. Using a fluorescence thermal shift assay, we identified stabilizing compounds that suggest potential natural ligands of Caci_0382. Using this information, we determined the crystal structure in complex with trimethylamine to provide a better understanding of the function of this uncharacterized protein.


==About this Structure==
Structural characterization of a hypothetical protein: a potential agent involved in trimethylamine metabolism in Catenulispora acidiphila.,Filippova EV, Luan CH, Dunne SF, Kiryukhina O, Minasov G, Shuvalova L, Anderson WF J Struct Funct Genomics. 2014 Mar;15(1):33-40. doi: 10.1007/s10969-014-9176-z., Epub 2014 Feb 22. PMID:24562475<ref>PMID:24562475</ref>
[[4hvn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Catad Catad]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HVN OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
<ref group="xtra">PMID:024562475</ref><references group="xtra"/><references/>
</div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Catad]]
[[Category: Catad]]
[[Category: Anderson, W F.]]
[[Category: Anderson, W F]]
[[Category: Filippova, E V.]]
[[Category: Filippova, E V]]
[[Category: Jedrzejczak, R.]]
[[Category: Jedrzejczak, R]]
[[Category: Joachimiak, A.]]
[[Category: Joachimiak, A]]
[[Category: Kiryukhina, O.]]
[[Category: Kiryukhina, O]]
[[Category: MCSG, Midwest Center for Structural Genomics.]]
[[Category: Structural genomic]]
[[Category: Minasov, G.]]
[[Category: Minasov, G]]
[[Category: Shuvalova, L.]]
[[Category: Shuvalova, L]]
[[Category: Mcsg]]
[[Category: Mcsg]]
[[Category: Midwest center for structural genomic]]
[[Category: Psi-biology]]
[[Category: Psi-biology]]
[[Category: Structural genomic]]
[[Category: Unknown function]]
[[Category: Unknown function]]
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