1z4u: Difference between revisions

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[[Image:1z4u.gif|left|200px]]<br /><applet load="1z4u" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1z4u.gif|left|200px]]
caption="1z4u, resolution 2.80&Aring;" />
 
'''hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00799585'''<br />
{{Structure
|PDB= 1z4u |SIZE=350|CAPTION= <scene name='initialview01'>1z4u</scene>, resolution 2.80&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=PH9:(2Z)-2-[(1-ADAMANTYLCARBONYL)AMINO]-3-[4-(2-BROMOPHENOXY)PHENYL]PROP-2-ENOIC+ACID'>PH9</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48]
|GENE=
}}
 
'''hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00799585'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1Z4U is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus] with <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=PH9:'>PH9</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4U OCA].  
1Z4U is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4U OCA].  


==Reference==
==Reference==
Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid., Pfefferkorn JA, Nugent R, Gross RJ, Greene M, Mitchell MA, Reding MT, Funk LA, Anderson R, Wells PA, Shelly JA, Anstadt R, Finzel BC, Harris MS, Kilkuskie RE, Kopta LA, Schwende FJ, Bioorg Med Chem Lett. 2005 Jun 2;15(11):2812-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15911260 15911260]
Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid., Pfefferkorn JA, Nugent R, Gross RJ, Greene M, Mitchell MA, Reding MT, Funk LA, Anderson R, Wells PA, Shelly JA, Anstadt R, Finzel BC, Harris MS, Kilkuskie RE, Kopta LA, Schwende FJ, Bioorg Med Chem Lett. 2005 Jun 2;15(11):2812-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15911260 15911260]
[[Category: Hepatitis c virus]]
[[Category: Hepatitis c virus]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: PH9]]
[[Category: PH9]]
[[Category: PO4]]
[[Category: PO4]]
[[Category: fingers]]
[[Category: finger]]
[[Category: hcv]]
[[Category: hcv]]
[[Category: ns5b]]
[[Category: ns5b]]
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[[Category: thumb]]
[[Category: thumb]]


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Retrieved from "https://proteopedia.org/1z4u"