2j1v: Difference between revisions
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==Overview== | ==Overview== | ||
The Streptococcus pneumoniae fucose utilization operon includes a gene, encoding a virulence factor that belongs to family 98 in the glycoside, hydrolase classification. This protein contains a C-terminal triplet of, fucose binding modules that have significant amino acid sequence identity, with the Anguilla anguilla fucolectin. Functional studies of these fucose, binding modules reveal binding to fucosylated oligosaccharides and suggest, the importance of multivalent binding. The high resolution crystal, structures of ligand bound forms of one fucose binding module uncovers the, molecular basis of fucose, ABH blood group antigen, and Lewisy antigen, binding. These studies are extended by fluorescence microscopy to show, specific binding to mouse lung tissue. These modules define a new . | The Streptococcus pneumoniae fucose utilization operon includes a gene, encoding a virulence factor that belongs to family 98 in the glycoside, hydrolase classification. This protein contains a C-terminal triplet of, fucose binding modules that have significant amino acid sequence identity, with the Anguilla anguilla fucolectin. Functional studies of these fucose, binding modules reveal binding to fucosylated oligosaccharides and suggest, the importance of multivalent binding. The high resolution crystal, structures of ligand bound forms of one fucose binding module uncovers the, molecular basis of fucose, ABH blood group antigen, and Lewisy antigen, binding. These studies are extended by fluorescence microscopy to show, specific binding to mouse lung tissue. These modules define a new family, of carbohydrate binding modules now classified as family 47. | ||
==About this Structure== | ==About this Structure== | ||
2J1V is a | 2J1V is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae] with NAG and CA as [http://en.wikipedia.org/wiki/ligands ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J1V OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: carbohydrate binding protein]] | [[Category: carbohydrate binding protein]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 13:14:29 2007'' | ||
