1z8a: Difference between revisions

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[[Image:1z8a.gif|left|200px]]<br /><applet load="1z8a" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1z8a.gif|left|200px]]
caption="1z8a, resolution 0.95&Aring;" />
 
'''Human Aldose Reductase complexed with novel Sulfonyl-pyridazinone Inhibitor'''<br />
{{Structure
|PDB= 1z8a |SIZE=350|CAPTION= <scene name='initialview01'>1z8a</scene>, resolution 0.95&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene> and <scene name='pdbligand=62P:6-[(5-CHLORO-3-METHYL-1-BENZOFURAN-2-YL)SULFONYL]PYRIDAZIN-3(2H)-ONE'>62P</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Aldehyde_reductase Aldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.21 1.1.1.21]
|GENE=
}}
 
'''Human Aldose Reductase complexed with novel Sulfonyl-pyridazinone Inhibitor'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1Z8A is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAP:'>NAP</scene> and <scene name='pdbligand=62P:'>62P</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Aldehyde_reductase Aldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.21 1.1.1.21] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z8A OCA].  
1Z8A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z8A OCA].  


==Reference==
==Reference==
High-resolution crystal structure of aldose reductase complexed with the novel sulfonyl-pyridazinone inhibitor exhibiting an alternative active site anchoring group., Steuber H, Zentgraf M, Podjarny A, Heine A, Klebe G, J Mol Biol. 2006 Feb 10;356(1):45-56. Epub 2005 Nov 10. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16337231 16337231]
High-resolution crystal structure of aldose reductase complexed with the novel sulfonyl-pyridazinone inhibitor exhibiting an alternative active site anchoring group., Steuber H, Zentgraf M, Podjarny A, Heine A, Klebe G, J Mol Biol. 2006 Feb 10;356(1):45-56. Epub 2005 Nov 10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16337231 16337231]
[[Category: Aldehyde reductase]]
[[Category: Aldehyde reductase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: tim-barrel]]
[[Category: tim-barrel]]


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