1kcp: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kcp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kcp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kcp RCSB], [http://www.ebi.ac.uk/pdbsum/1kcp PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kcp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kcp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kcp RCSB], [http://www.ebi.ac.uk/pdbsum/1kcp PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/CXK7A_CONPU CXK7A_CONPU]] Kappa-conotoxins bind and inhibit voltage-gated potassium channels (Kv). This toxin inhibits the Shaker channel from insects. The interaction site between the Shaker channel and this toxin is within the S5-S6 loop of the Shaker channel. In fish, this toxin induces hyperactivity, followed by continuous contraction and extension of major fins, without immobilization or death. Injection of this peptide together with the delta-conotoxin PVIA causes the sudden tetanus of prey (STOP) syndrome, which is a single, lethal "fin-pop" in envenomed fish. In mice, induces hyperactivity.<ref>PMID:9417043</ref> <ref>PMID:12074021</ref> <ref>PMID:10398696</ref> <ref>PMID:12023223</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
