1emo: Difference between revisions
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==Overview== | ==Overview== | ||
The nuclear magnetic resonance structure of a covalently linked pair of, calcium-binding (cb) epidermal growth factor-like (EGF) domains from human, fibrillin-1, the protein defective in the Marfan syndrome, is described., The two domains are in a rigid, rod-like arrangement, stabilized by, interdomain calcium binding and hydrophobic interactions. We propose a, model for the arrangement of fibrillin monomers in microfibrils that, reconciles structural and antibody binding data, and we describe a set of, disease-causing mutations that provide the first clues to the specificity, of cbEFG interactions. The residues involved in stabilizing the domain, linkage are highly conserved in fibrillin, fibulin, thrombomodulin, and, the low density lipoprotein receptor. We propose that the relative, . | The nuclear magnetic resonance structure of a covalently linked pair of, calcium-binding (cb) epidermal growth factor-like (EGF) domains from human, fibrillin-1, the protein defective in the Marfan syndrome, is described., The two domains are in a rigid, rod-like arrangement, stabilized by, interdomain calcium binding and hydrophobic interactions. We propose a, model for the arrangement of fibrillin monomers in microfibrils that, reconciles structural and antibody binding data, and we describe a set of, disease-causing mutations that provide the first clues to the specificity, of cbEFG interactions. The residues involved in stabilizing the domain, linkage are highly conserved in fibrillin, fibulin, thrombomodulin, and, the low density lipoprotein receptor. We propose that the relative, orientation of tandem cbEGF domains in these proteins is similar, but that, in others, including Notch, pairs adopt a completely different, conformation. | ||
==About this Structure== | ==About this Structure== | ||
1EMO is a | 1EMO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Structure known Active Sites: CA1 and CA2. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1EMO OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: signal]] | [[Category: signal]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 13:15:25 2007'' | ||
