1ze8: Difference between revisions

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[[Image:1ze8.gif|left|200px]]<br /><applet load="1ze8" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1ze8.gif|left|200px]]
caption="1ze8, resolution 2.0&Aring;" />
 
'''Carbonic anhydrase II in complex with a membrane-impermeant sulfonamide inhibitor'''<br />
{{Structure
|PDB= 1ze8 |SIZE=350|CAPTION= <scene name='initialview01'>1ze8</scene>, resolution 2.0&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=HGB:4-(HYDROXYMERCURY)BENZOIC+ACID'>HGB</scene>, <scene name='pdbligand=PIU:1-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}-2,4,6-TRIMETHYLPYRIDINIUM'>PIU</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1]
|GENE=
}}
 
'''Carbonic anhydrase II in complex with a membrane-impermeant sulfonamide inhibitor'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1ZE8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=HGB:'>HGB</scene>, <scene name='pdbligand=PIU:'>PIU</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZE8 OCA].  
1ZE8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZE8 OCA].  


==Reference==
==Reference==
Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II., Menchise V, De Simone G, Alterio V, Di Fiore A, Pedone C, Scozzafava A, Supuran CT, J Med Chem. 2005 Sep 8;48(18):5721-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16134940 16134940]
Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II., Menchise V, De Simone G, Alterio V, Di Fiore A, Pedone C, Scozzafava A, Supuran CT, J Med Chem. 2005 Sep 8;48(18):5721-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16134940 16134940]
[[Category: Carbonate dehydratase]]
[[Category: Carbonate dehydratase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: twisted beta-sheet]]
[[Category: twisted beta-sheet]]


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