1zgi: Difference between revisions

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[[Image:1zgi.jpg|left|200px]]<br /><applet load="1zgi" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1zgi.jpg|left|200px]]
caption="1zgi, resolution 2.2&Aring;" />
 
'''thrombin in complex with an oxazolopyridine inhibitor 21'''<br />
{{Structure
|PDB= 1zgi |SIZE=350|CAPTION= <scene name='initialview01'>1zgi</scene>, resolution 2.2&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=382:(R)-2-(2-(1H-1,2,4-TRIAZOL-1-YL)BENZYL)-N-(2,2-DIFLUORO-2-(PIPERIDIN-2-YL)ETHYL)OXAZOLO[4,5-C]PYRIDIN-4-AMINE'>382</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5]
|GENE=
}}
 
'''thrombin in complex with an oxazolopyridine inhibitor 21'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1ZGI is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=382:'>382</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZGI OCA].  
1ZGI is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZGI OCA].  


==Reference==
==Reference==
Development of an oxazolopyridine series of dual thrombin/factor Xa inhibitors via structure-guided lead optimization., Deng JZ, McMasters DR, Rabbat PM, Williams PD, Coburn CA, Yan Y, Kuo LC, Lewis SD, Lucas BJ, Krueger JA, Strulovici B, Vacca JP, Lyle TA, Burgey CS, Bioorg Med Chem Lett. 2005 Oct 15;15(20):4411-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16137886 16137886]
Development of an oxazolopyridine series of dual thrombin/factor Xa inhibitors via structure-guided lead optimization., Deng JZ, McMasters DR, Rabbat PM, Williams PD, Coburn CA, Yan Y, Kuo LC, Lewis SD, Lucas BJ, Krueger JA, Strulovici B, Vacca JP, Lyle TA, Burgey CS, Bioorg Med Chem Lett. 2005 Oct 15;15(20):4411-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16137886 16137886]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: thrombin inhibitor complex]]
[[Category: thrombin inhibitor complex]]


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