4tkf: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tkf RCSB], [http://www.ebi.ac.uk/pdbsum/4tkf PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tkf RCSB], [http://www.ebi.ac.uk/pdbsum/4tkf PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Battaile, K P | [[Category: Battaile, K P]] | ||
[[Category: Beletskaya, I | [[Category: Beletskaya, I]] | ||
[[Category: Chirgadze, N Y | [[Category: Chirgadze, N Y]] | ||
[[Category: Gebremeskel, S | [[Category: Gebremeskel, S]] | ||
[[Category: Gordon, R | [[Category: Gordon, R]] | ||
[[Category: Lam, R | [[Category: Lam, R]] | ||
[[Category: Pai, E F | [[Category: Pai, E F]] | ||
[[Category: Qiu, W | [[Category: Qiu, W]] | ||
[[Category: Romanov, V | [[Category: Romanov, V]] | ||
[[Category: Thompson, C | [[Category: Thompson, C]] | ||
[[Category: Vodsedalek, J | [[Category: Vodsedalek, J]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
