2ez5: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ez5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EZ5 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2ez5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EZ5 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ez5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ez5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ez5 RCSB], [http://www.ebi.ac.uk/pdbsum/2ez5 PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ez5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ez5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ez5 RCSB], [http://www.ebi.ac.uk/pdbsum/2ez5 PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/NEDD4_DROME NEDD4_DROME]] Essential E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Notch/N signaling pathway by promoting Notch ubiquitination, endocytosis and degradation.<ref>PMID:12165468</ref> <ref>PMID:15620649</ref> <ref>PMID:15657595</ref> [[http://www.uniprot.org/uniprot/COMM_DROME COMM_DROME]] Controls axon guidance across the CNS midline by preventing the delivery of Robo to the growth cone.<ref>PMID:12165468</ref> <ref>PMID:15657595</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
[[Category: Bruce, M C | [[Category: Bruce, M C]] | ||
[[Category: Forman-Kay, J D | [[Category: Forman-Kay, J D]] | ||
[[Category: Kanelis, V | [[Category: Kanelis, V]] | ||
[[Category: Rotin, D | [[Category: Rotin, D]] | ||
[[Category: Skrynnikov, N R | [[Category: Skrynnikov, N R]] | ||
[[Category: Binding affinity]] | [[Category: Binding affinity]] | ||
[[Category: Commissureless]] | [[Category: Commissureless]] | ||
