4dz5: Difference between revisions

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[[~~Image~~:~~4dz5~~.~~jpg~~|~~left~~|~~200px~~]]

==W227F active site mutant of AKR1C3==

== Structural highlights ==

<table><tr><td colspan='2'>[[4dz5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DZ5 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DZ5 FirstGlance].

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">AKR1C3, DDH1, HSD17B5, KIAA0119, PGFS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dz5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dz5 RCSB], [http://www.ebi.ac.uk/pdbsum/4dz5 PDBsum]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN]] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.

~~{{STRUCTURE_4dz5| PDB=4dz5 | SCENE= }}~~

==See Also==

*[[Prostaglandin F synthase|Prostaglandin F synthase]]

~~===W227F active site mutant of AKR1C3===~~

__TOC__

</StructureSection>

==~~About this Structure~~==

[[~~4dz5~~]] ~~is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki~~/~~Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DZ5 OCA].~~

[[Category: Homo sapiens]]

[[Category: Flanagan, J U.]]

[[Category: Flanagan, J U]]

[[Category: Squire, C J.]]

[[Category: Squire, C J]]

[[Category: Yosaatmadja, Y.]]

[[Category: Yosaatmadja, Y]]

[[Category: Oxidoreductase]]

[[Category: Tim barrel]]

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-[[Image:4dz5.jpg|left|200px]]
+==W227F active site mutant of AKR1C3==
+<StructureSection load='4dz5' size='340' side='right' caption='[[4dz5]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4dz5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DZ5 FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AKR1C3, DDH1, HSD17B5, KIAA0119, PGFS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dz5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dz5 RCSB], [http://www.ebi.ac.uk/pdbsum/4dz5 PDBsum]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN]] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
-{{STRUCTURE_4dz5|  PDB=4dz5  |  SCENE=  }}
+==See Also==
+*[[Prostaglandin F synthase|Prostaglandin F synthase]]
-===W227F active site mutant of AKR1C3===
+__TOC__
+</StructureSection>
-==About this Structure==
-[[4dz5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DZ5 OCA].
 [[Category: Homo sapiens]]
-[[Category: Flanagan, J U.]]
+[[Category: Flanagan, J U]]
-[[Category: Squire, C J.]]
+[[Category: Squire, C J]]
-[[Category: Yosaatmadja, Y.]]
+[[Category: Yosaatmadja, Y]]
 [[Category: Oxidoreductase]]
 [[Category: Tim barrel]]