1ztz: Difference between revisions

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[[Image:1ztz.jpg|left|200px]]<br /><applet load="1ztz" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1ztz.jpg|left|200px]]
caption="1ztz, resolution 2.15&Aring;" />
 
'''Crystal structure of HIV protease- metallacarborane complex'''<br />
{{Structure
|PDB= 1ztz |SIZE=350|CAPTION= <scene name='initialview01'>1ztz</scene>, resolution 2.15&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=CB5:COBALT BIS(1,2-DICARBOLLIDE)'>CB5</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16]
|GENE= gag-pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
}}
 
'''Crystal structure of HIV protease- metallacarborane complex'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1ZTZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=CB5:'>CB5</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZTZ OCA].  
1ZTZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZTZ OCA].  


==Reference==
==Reference==
From nonpeptide toward noncarbon protease inhibitors: metallacarboranes as specific and potent inhibitors of HIV protease., Cigler P, Kozisek M, Rezacova P, Brynda J, Otwinowski Z, Pokorna J, Plesek J, Gruner B, Doleckova-Maresova L, Masa M, Sedlacek J, Bodem J, Krausslich HG, Kral V, Konvalinka J, Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15394-9. Epub 2005 Oct 14. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16227435 16227435]
From nonpeptide toward noncarbon protease inhibitors: metallacarboranes as specific and potent inhibitors of HIV protease., Cigler P, Kozisek M, Rezacova P, Brynda J, Otwinowski Z, Pokorna J, Plesek J, Gruner B, Doleckova-Maresova L, Masa M, Sedlacek J, Bodem J, Krausslich HG, Kral V, Konvalinka J, Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15394-9. Epub 2005 Oct 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16227435 16227435]
[[Category: HIV-1 retropepsin]]
[[Category: HIV-1 retropepsin]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: Sedlacek, J.]]
[[Category: Sedlacek, J.]]
[[Category: CB5]]
[[Category: CB5]]
[[Category: rational drug design; hiv protease inhibitors; aspartic proteases; carboranes; metallacarboranes]]
[[Category: rational drug design; hiv protease inhibitors; aspartic proteases; carboranes; metallacarborane]]


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