4ehr: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ehr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EHR FirstGlance]. <br> | <table><tr><td colspan='2'>[[4ehr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EHR FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0Q5:4-[5-BUTYL-3-(HYDROXYMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL]-3-(3,4-DIHYDROISOQUINOLIN-2(1H)-YLCARBONYL)-N-{[2-(TRIMETHYLSILYL)ETHYL]SULFONYL}BENZAMIDE'>0Q5</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0Q5:4-[5-BUTYL-3-(HYDROXYMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL]-3-(3,4-DIHYDROISOQUINOLIN-2(1H)-YLCARBONYL)-N-{[2-(TRIMETHYLSILYL)ETHYL]SULFONYL}BENZAMIDE'>0Q5</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BCL2L1, BCL2L, BCLX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BCL2L1, BCL2L, BCLX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ehr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ehr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ehr RCSB], [http://www.ebi.ac.uk/pdbsum/4ehr PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ehr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ehr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ehr RCSB], [http://www.ebi.ac.uk/pdbsum/4ehr PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Banfi, P | [[Category: Banfi, P]] | ||
[[Category: Borzilleri, R M | [[Category: Borzilleri, R M]] | ||
[[Category: Cai, Z | [[Category: Cai, Z]] | ||
[[Category: Galvani, A | [[Category: Galvani, A]] | ||
[[Category: Lippy, J | [[Category: Lippy, J]] | ||
[[Category: Lombardo, L J | [[Category: Lombardo, L J]] | ||
[[Category: Menichincheri, M | [[Category: Menichincheri, M]] | ||
[[Category: Modugno, M | [[Category: Modugno, M]] | ||
[[Category: Naglich, J | [[Category: Naglich, J]] | ||
[[Category: Penhallow, B | [[Category: Penhallow, B]] | ||
[[Category: Perez, H L | [[Category: Perez, H L]] | ||
[[Category: Sack, J | [[Category: Sack, J]] | ||
[[Category: Schmidt, R J | [[Category: Schmidt, R J]] | ||
[[Category: Schroeder, G M | [[Category: Schroeder, G M]] | ||
[[Category: Tebben, A | [[Category: Tebben, A]] | ||
[[Category: Wei, D | [[Category: Wei, D]] | ||
[[Category: Yan, C | [[Category: Yan, C]] | ||
[[Category: Zhang, L | [[Category: Zhang, L]] | ||
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
[[Category: Bcl-2 family]] | [[Category: Bcl-2 family]] | ||
[[Category: Programmed cell death]] | [[Category: Programmed cell death]] | ||
