2a2x: Difference between revisions

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[[Image:2a2x.jpg|left|200px]]<br /><applet load="2a2x" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2a2x.jpg|left|200px]]
caption="2a2x, resolution 2.440&Aring;" />
 
'''Orally Active Thrombin Inhibitors in Complex with Thrombin Inh12'''<br />
{{Structure
|PDB= 2a2x |SIZE=350|CAPTION= <scene name='initialview01'>2a2x</scene>, resolution 2.440&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=NA9:N-(CARBOXYMETHYL)-3-CYCLOHEXYL-D-ALANYL-N-({6-[AMINO(IMINO)METHYL]PYRIDIN-3-YL}METHYL)-N~2~-METHYL-L-ALANINAMIDE'>NA9</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5]
|GENE=
}}
 
'''Orally Active Thrombin Inhibitors in Complex with Thrombin Inh12'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2A2X is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NA9:'>NA9</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2X OCA].  
2A2X is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2X OCA].  


==Reference==
==Reference==
Orally active thrombin inhibitors. Part 2: optimization of the P2-moiety., Lange UE, Baucke D, Hornberger W, Mack H, Seitz W, Hoffken HW, Bioorg Med Chem Lett. 2006 May 15;16(10):2648-53. Epub 2006 Feb 3. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16460939 16460939]
Orally active thrombin inhibitors. Part 2: optimization of the P2-moiety., Lange UE, Baucke D, Hornberger W, Mack H, Seitz W, Hoffken HW, Bioorg Med Chem Lett. 2006 May 15;16(10):2648-53. Epub 2006 Feb 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16460939 16460939]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: serine protease]]
[[Category: serine protease]]


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