4ctm: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ctm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CTM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CTM FirstGlance]. <br> | <table><tr><td colspan='2'>[[4ctm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CTM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CTM FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MIF:(5R,7R,8S,9S,10R)-8,9,10-TRIHYDROXY-7-(HYDROXYMETHYL)-2-IMINO-6-OXA-1-THIA-3-AZASPIRO[4.5]DECAN-4-ONE'>MIF</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MIF:(5R,7R,8S,9S,10R)-8,9,10-TRIHYDROXY-7-(HYDROXYMETHYL)-2-IMINO-6-OXA-1-THIA-3-AZASPIRO[4.5]DECAN-4-ONE'>MIF</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ctn|4ctn]], [[4cto|4cto]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ctn|4ctn]], [[4cto|4cto]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ctm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ctm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ctm RCSB], [http://www.ebi.ac.uk/pdbsum/4ctm PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ctm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ctm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ctm RCSB], [http://www.ebi.ac.uk/pdbsum/4ctm PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/PYGM_RABIT PYGM_RABIT]] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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[[Category: Oryctolagus cuniculus]] | [[Category: Oryctolagus cuniculus]] | ||
[[Category: Phosphorylase]] | [[Category: Phosphorylase]] | ||
[[Category: Alexacou, K M | [[Category: Alexacou, K M]] | ||
[[Category: Chrysina, E D | [[Category: Chrysina, E D]] | ||
[[Category: Leonidas, D D | [[Category: Leonidas, D D]] | ||
[[Category: Papakonstantinou, M | [[Category: Papakonstantinou, M]] | ||
[[Category: Zographos, S E | [[Category: Zographos, S E]] | ||
[[Category: Inhibitor]] | [[Category: Inhibitor]] | ||
[[Category: Structure-based drug design]] | [[Category: Structure-based drug design]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
[[Category: Type 2 diabetes]] | [[Category: Type 2 diabetes]] | ||
