1t32: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1t32]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T32 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T32 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1t32]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T32 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T32 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OHH:2-[3-({METHYL[1-(2-NAPHTHOYL)PIPERIDIN-4-YL]AMINO}CARBONYL)-2-NAPHTHYL]-1-(1-NAPHTHYL)-2-OXOETHYLPHOSPHONIC+ACID'>OHH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OHH:2-[3-({METHYL[1-(2-NAPHTHOYL)PIPERIDIN-4-YL]AMINO}CARBONYL)-2-NAPHTHYL]-1-(1-NAPHTHYL)-2-OXOETHYLPHOSPHONIC+ACID'>OHH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cgh|1cgh]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cgh|1cgh]]</td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HUMAN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HUMAN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_G Cathepsin G], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.20 3.4.21.20] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_G Cathepsin G], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.20 3.4.21.20] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t32 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t32 RCSB], [http://www.ebi.ac.uk/pdbsum/1t32 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t32 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t32 RCSB], [http://www.ebi.ac.uk/pdbsum/1t32 PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/CATG_HUMAN CATG_HUMAN]] Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.<ref>PMID:8194606</ref> <ref>PMID:1861080</ref> <ref>PMID:1937776</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Cathepsin G]] | [[Category: Cathepsin G]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Abraham, W M | [[Category: Abraham, W M]] | ||
[[Category: Andrade-Gordon, P | [[Category: Andrade-Gordon, P]] | ||
[[Category: Cera, E Di | [[Category: Cera, E Di]] | ||
[[Category: Chen, Z | [[Category: Chen, Z]] | ||
[[Category: Corcoran, T W | [[Category: Corcoran, T W]] | ||
[[Category: Damiano, B P | [[Category: Damiano, B P]] | ||
[[Category: Derian, C K | [[Category: Derian, C K]] | ||
[[Category: Eckardt, A J | [[Category: Eckardt, A J]] | ||
[[Category: Garavilla, L de | [[Category: Garavilla, L de]] | ||
[[Category: Giardino, E C | [[Category: Giardino, E C]] | ||
[[Category: Greco, M N | [[Category: Greco, M N]] | ||
[[Category: Haertlein, B J | [[Category: Haertlein, B J]] | ||
[[Category: Kauffman, J A | [[Category: Kauffman, J A]] | ||
[[Category: Maryanoff, B E | [[Category: Maryanoff, B E]] | ||
[[Category: Mathews, F S | [[Category: Mathews, F S]] | ||
[[Category: Pineda, A O | [[Category: Pineda, A O]] | ||
[[Category: Sukumar, N | [[Category: Sukumar, N]] | ||
[[Category: Wells, G I | [[Category: Wells, G I]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Inflammation inhibitor serine protease]] | [[Category: Inflammation inhibitor serine protease]] | ||
