2am9: Difference between revisions

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[[Image:2am9.gif|left|200px]]<br /><applet load="2am9" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2am9.gif|left|200px]]
caption="2am9, resolution 1.640&Aring;" />
 
'''Crystal structure of human androgen receptor ligand binding domain in complex with testosterone'''<br />
{{Structure
|PDB= 2am9 |SIZE=350|CAPTION= <scene name='initialview01'>2am9</scene>, resolution 1.640&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TES:TESTOSTERONE'>TES</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
|ACTIVITY=
|GENE= AR, DHTR, NR3C4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Crystal structure of human androgen receptor ligand binding domain in complex with testosterone'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2AM9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=TES:'>TES</scene>, <scene name='pdbligand=DTT:'>DTT</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 2AM9 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb92_1.html Anabolic Steroids]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AM9 OCA].  
2AM9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 2AM9 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb92_1.html Anabolic Steroids]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AM9 OCA].  


==Reference==
==Reference==
Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity., Pereira de Jesus-Tran K, Cote PL, Cantin L, Blanchet J, Labrie F, Breton R, Protein Sci. 2006 May;15(5):987-99. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16641486 16641486]
Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity., Pereira de Jesus-Tran K, Cote PL, Cantin L, Blanchet J, Labrie F, Breton R, Protein Sci. 2006 May;15(5):987-99. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16641486 16641486]
[[Category: Anabolic Steroids]]
[[Category: Anabolic Steroids]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: testosterone]]
[[Category: testosterone]]


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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:51:14 2008''
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