2zvn: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2zvn]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZVN FirstGlance]. <br> | <table><tr><td colspan='2'>[[2zvn]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZVN FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2zvo|2zvo]], [[3f89|3f89]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2zvo|2zvo]], [[3f89|3f89]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zvn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zvn RCSB], [http://www.ebi.ac.uk/pdbsum/2zvn PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zvn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zvn RCSB], [http://www.ebi.ac.uk/pdbsum/2zvn PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/NEMO_MOUSE NEMO_MOUSE]] Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (By similarity).<ref>PMID:9927690</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Akutsu, M | [[Category: Akutsu, M]] | ||
[[Category: Bloor, S | [[Category: Bloor, S]] | ||
[[Category: Dikic, I | [[Category: Dikic, I]] | ||
[[Category: Ikeda, F | [[Category: Ikeda, F]] | ||
[[Category: Kato, R | [[Category: Kato, R]] | ||
[[Category: Kawasaki, M | [[Category: Kawasaki, M]] | ||
[[Category: Kensche, T | [[Category: Kensche, T]] | ||
[[Category: Komander, D | [[Category: Komander, D]] | ||
[[Category: Rahighi, S | [[Category: Rahighi, S]] | ||
[[Category: Randow, F | [[Category: Randow, F]] | ||
[[Category: Suzuki, N | [[Category: Suzuki, N]] | ||
[[Category: Uejima, T | [[Category: Uejima, T]] | ||
[[Category: Wakatsuki, S | [[Category: Wakatsuki, S]] | ||
[[Category: Metal-binding]] | [[Category: Metal-binding]] | ||
[[Category: Nf-kb signaling]] | [[Category: Nf-kb signaling]] | ||
