4kk2: Difference between revisions
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==Crystal structure of a chimeric FPP/GFPP synthase (TARGET EFI-502313c) from Artemisia spiciformiS (1-72:GI751454468,73-346:GI75233326), apo structure== | |||
<StructureSection load='4kk2' size='340' side='right' caption='[[4kk2]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | |||
==Function== | <table><tr><td colspan='2'>[[4kk2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Artemisia_spiciformis Artemisia spiciformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KK2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KK2 FirstGlance]. <br> | ||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FDS-5, FDS-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=235357 Artemisia spiciformis])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kk2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kk2 RCSB], [http://www.ebi.ac.uk/pdbsum/4kk2 PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/CHRDS_ARTSI CHRDS_ARTSI]] Condenses two molecules of dimethylallyl diphosphate (DMAPP) to produce mainly an irregular monoterpene, chrysanthemyl diphosphate (CPP) and lower amounts of a branched monoterpene, lavandulyl diphosphate (LPP). CPP is a precursor of the pyrethrin insecticides. When incubated with isopentenyl diphosphate (IPP) and DMAPP, catalyzes three competing isoprenoid condensation reactions, a chain elongation to give geranyl diphosphate (GPP), a cyclopropanation to give CPP and a branching to give LPP.<ref>PMID:12782626</ref> | [[http://www.uniprot.org/uniprot/CHRDS_ARTSI CHRDS_ARTSI]] Condenses two molecules of dimethylallyl diphosphate (DMAPP) to produce mainly an irregular monoterpene, chrysanthemyl diphosphate (CPP) and lower amounts of a branched monoterpene, lavandulyl diphosphate (LPP). CPP is a precursor of the pyrethrin insecticides. When incubated with isopentenyl diphosphate (IPP) and DMAPP, catalyzes three competing isoprenoid condensation reactions, a chain elongation to give geranyl diphosphate (GPP), a cyclopropanation to give CPP and a branching to give LPP.<ref>PMID:12782626</ref> | ||
== References == | |||
== | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
<references | |||
[[Category: Artemisia spiciformis]] | [[Category: Artemisia spiciformis]] | ||
[[Category: Almo, S C | [[Category: Almo, S C]] | ||
[[Category: Bhosle, R | [[Category: Bhosle, R]] | ||
[[Category: Chowdhury, S | [[Category: Chowdhury, S]] | ||
[[Category: Evans, B | [[Category: Evans, B]] | ||
[[Category: Gerlt, J A | [[Category: Gerlt, J A]] | ||
[[Category: Glenn, A Scott | [[Category: Glenn, A Scott]] | ||
[[Category: Hammonds, J | [[Category: Hammonds, J]] | ||
[[Category: Hillerich, B | [[Category: Hillerich, B]] | ||
[[Category: Imker, H J | [[Category: Imker, H J]] | ||
[[Category: Initiative, Enzyme Function | [[Category: Initiative, Enzyme Function]] | ||
[[Category: Love, J | [[Category: Love, J]] | ||
[[Category: Obaidi, N F.Al | [[Category: Obaidi, N F.Al]] | ||
[[Category: Poulter, C D | [[Category: Poulter, C D]] | ||
[[Category: Seidel, R D | [[Category: Seidel, R D]] | ||
[[Category: Toro, R | [[Category: Toro, R]] | ||
[[Category: Vetting, M W | [[Category: Vetting, M W]] | ||
[[Category: Washington, E | [[Category: Washington, E]] | ||
[[Category: Enzyme function initiative]] | [[Category: Enzyme function initiative]] | ||
[[Category: Isoprenoid synthase]] | [[Category: Isoprenoid synthase]] | ||
[[Category: Structural genomic]] | [[Category: Structural genomic]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 01:55, 25 December 2014
Crystal structure of a chimeric FPP/GFPP synthase (TARGET EFI-502313c) from Artemisia spiciformiS (1-72:GI751454468,73-346:GI75233326), apo structure
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