2ax0: Difference between revisions

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[[Image:2ax0.gif|left|200px]]<br /><applet load="2ax0" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2ax0.gif|left|200px]]
caption="2ax0, resolution 2.00&Aring;" />
 
'''Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5x)'''<br />
{{Structure
|PDB= 2ax0 |SIZE=350|CAPTION= <scene name='initialview01'>2ax0</scene>, resolution 2.00&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=5X:5R-(2E-METHYL-3-PHENYL-ALLYL)-3-(BENZENESULFONYLAMINO)-4-OXO-2-THIONOTHIAZOLIDINE'>5X</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48]
|GENE=
}}
 
'''Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5x)'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2AX0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=5X:'>5X</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AX0 OCA].  
2AX0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AX0 OCA].  


==Reference==
==Reference==
SAR and mode of action of novel non-nucleoside inhibitors of hepatitis C NS5b RNA polymerase., Powers JP, Piper DE, Li Y, Mayorga V, Anzola J, Chen JM, Jaen JC, Lee G, Liu J, Peterson MG, Tonn GR, Ye Q, Walker NP, Wang Z, J Med Chem. 2006 Feb 9;49(3):1034-46. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16451069 16451069]
SAR and mode of action of novel non-nucleoside inhibitors of hepatitis C NS5b RNA polymerase., Powers JP, Piper DE, Li Y, Mayorga V, Anzola J, Chen JM, Jaen JC, Lee G, Liu J, Peterson MG, Tonn GR, Ye Q, Walker NP, Wang Z, J Med Chem. 2006 Feb 9;49(3):1034-46. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16451069 16451069]
[[Category: Hepatitis c virus]]
[[Category: Hepatitis c virus]]
[[Category: RNA-directed RNA polymerase]]
[[Category: RNA-directed RNA polymerase]]
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[[Category: 5X]]
[[Category: 5X]]
[[Category: SO4]]
[[Category: SO4]]
[[Category: fingers]]
[[Category: finger]]
[[Category: hcv]]
[[Category: hcv]]
[[Category: ns5b]]
[[Category: ns5b]]
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[[Category: thumb]]
[[Category: thumb]]


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