2az5: Difference between revisions

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[[Image:2az5.gif|left|200px]]<br /><applet load="2az5" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2az5.gif|left|200px]]
caption="2az5, resolution 2.100&Aring;" />
 
'''Crystal Structure of TNF-alpha with a small molecule inhibitor'''<br />
{{Structure
|PDB= 2az5 |SIZE=350|CAPTION= <scene name='initialview01'>2az5</scene>, resolution 2.100&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=307:6,7-DIMETHYL-3-[(METHYL{2-[METHYL({1-[3-(TRIFLUOROMETHYL)PHENYL]-1H-INDOL-3-YL}METHYL)AMINO]ETHYL}AMINO)METHYL]-4H-CHROMEN-4-ONE'>307</scene>
|ACTIVITY=
|GENE= TNF, TNFA, TNFSF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Crystal Structure of TNF-alpha with a small molecule inhibitor'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2AZ5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=307:'>307</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZ5 OCA].  
2AZ5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZ5 OCA].  


==Reference==
==Reference==
Small-molecule inhibition of TNF-alpha., He MM, Smith AS, Oslob JD, Flanagan WM, Braisted AC, Whitty A, Cancilla MT, Wang J, Lugovskoy AA, Yoburn JC, Fung AD, Farrington G, Eldredge JK, Day ES, Cruz LA, Cachero TG, Miller SK, Friedman JE, Choong IC, Cunningham BC, Science. 2005 Nov 11;310(5750):1022-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16284179 16284179]
Small-molecule inhibition of TNF-alpha., He MM, Smith AS, Oslob JD, Flanagan WM, Braisted AC, Whitty A, Cancilla MT, Wang J, Lugovskoy AA, Yoburn JC, Fung AD, Farrington G, Eldredge JK, Day ES, Cruz LA, Cachero TG, Miller SK, Friedman JE, Choong IC, Cunningham BC, Science. 2005 Nov 11;310(5750):1022-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16284179 16284179]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: tnf-alpha trimer disruption by binding of a small molecule inhibitor]]
[[Category: tnf-alpha trimer disruption by binding of a small molecule inhibitor]]


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