3j1x: Difference between revisions
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==A refined model of the prototypical Salmonella typhimurium T3SS basal body reveals the molecular basis for its assembly== | |||
<StructureSection load='3j1x' size='340' side='right' caption='[[3j1x]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3j1x]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_typhimurium"_loeffler_1892 "bacillus typhimurium" loeffler 1892]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J1X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J1X FirstGlance]. <br> | |||
==Function== | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4g08|4g08]], [[4g1i|4g1i]], [[3j1v|3j1v]], [[3j1w|3j1w]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j1x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j1x RCSB], [http://www.ebi.ac.uk/pdbsum/3j1x PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PRGH_SALTY PRGH_SALTY]] Required for invasion of epithelial cells. | [[http://www.uniprot.org/uniprot/PRGH_SALTY PRGH_SALTY]] Required for invasion of epithelial cells. | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Type III secretion systems (T3SSs) are essential virulence factors used by many Gram-negative bacteria to inject proteins that make eukaryotic host cells accessible to invasion. The T3SS core structure, the needle complex (NC), is a ~3.5 megadalton-sized, oligomeric, membrane-embedded complex. Analyzing cryo-electron microscopy images of top views of NCs or NC substructures from Salmonella typhimurium revealed a 24-fold symmetry for the inner rings and a 15-fold symmetry for the outer rings, giving an overall C3 symmetry. Local refinement and averaging showed the organization of the central core and allowed us to reconstruct a subnanometer composite structure of the NC, which together with confident docking of atomic structures reveal insights into its overall organization and structural requirements during assembly. | |||
Three-dimensional model of Salmonella's needle complex at subnanometer resolution.,Schraidt O, Marlovits TC Science. 2011 Mar 4;331(6021):1192-5. PMID:21385715<ref>PMID:21385715</ref> | |||
== | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | |||
[[Category: | == References == | ||
[[Category: Baker, D | <references/> | ||
[[Category: Bergeron, J R.C | __TOC__ | ||
[[Category: Sgourakis, N G | </StructureSection> | ||
[[Category: Strynadka, N C.J | [[Category: Bacillus typhimurium loeffler 1892]] | ||
[[Category: Worrall, L J | [[Category: Baker, D]] | ||
[[Category: Bergeron, J R.C]] | |||
[[Category: Sgourakis, N G]] | |||
[[Category: Strynadka, N C.J]] | |||
[[Category: Worrall, L J]] | |||
[[Category: Cell invasion]] | [[Category: Cell invasion]] | ||
[[Category: T3ss]] | [[Category: T3ss]] | ||
