4o2w: Difference between revisions
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==Crystal structure of the third RCC1-like domain of HERC1== | |||
<StructureSection load='4o2w' size='340' side='right' caption='[[4o2w]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
==Function== | <table><tr><td colspan='2'>[[4o2w]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O2W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O2W FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HERC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o2w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o2w RCSB], [http://www.ebi.ac.uk/pdbsum/4o2w PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/HERC1_HUMAN HERC1_HUMAN]] Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.<ref>PMID:8861955</ref> <ref>PMID:9233772</ref> <ref>PMID:15642342</ref> | [[http://www.uniprot.org/uniprot/HERC1_HUMAN HERC1_HUMAN]] Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.<ref>PMID:8861955</ref> <ref>PMID:9233772</ref> <ref>PMID:15642342</ref> | ||
== | ==See Also== | ||
[[ | *[[Ubiquitin protein ligase|Ubiquitin protein ligase]] | ||
== References == | |||
== | <references/> | ||
<references | __TOC__ | ||
[[Category: Arrowsmith, C H | </StructureSection> | ||
[[Category: Bountra, C | [[Category: Human]] | ||
[[Category: Dong, A | [[Category: Arrowsmith, C H]] | ||
[[Category: Edwards, A M | [[Category: Bountra, C]] | ||
[[Category: Hu, J | [[Category: Dong, A]] | ||
[[Category: Li, Y | [[Category: Edwards, A M]] | ||
[[Category: | [[Category: Hu, J]] | ||
[[Category: Tong, Y | [[Category: Li, Y]] | ||
[[Category: Walker, J R | [[Category: Structural genomic]] | ||
[[Category: Tong, Y]] | |||
[[Category: Walker, J R]] | |||
[[Category: Beta-propeller]] | [[Category: Beta-propeller]] | ||
[[Category: Herc1]] | [[Category: Herc1]] | ||
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[[Category: Rld]] | [[Category: Rld]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
Revision as of 02:52, 25 December 2014
Crystal structure of the third RCC1-like domain of HERC1
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