2b55: Difference between revisions

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[[Image:2b55.gif|left|200px]]<br /><applet load="2b55" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2b55.gif|left|200px]]
caption="2b55, resolution 1.85&Aring;" />
 
'''Human cyclin dependent kinase 2 (cdk2) complexed with indenopyraxole DIN-101312'''<br />
{{Structure
|PDB= 2b55 |SIZE=350|CAPTION= <scene name='initialview01'>2b55</scene>, resolution 1.85&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=D31:2-(4-(AMINOMETHYL)PIPERIDIN-1-YL)-N-(3_CYCLOHEXYL-4-OXO-2,4-DIHYDROINDENO[1,2-C]PYRAZOL-5-YL)ACETAMIDE'>D31</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1]
|GENE=
}}
 
'''Human cyclin dependent kinase 2 (cdk2) complexed with indenopyraxole DIN-101312'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2B55 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=D31:'>D31</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B55 OCA].  
2B55 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B55 OCA].  


==Reference==
==Reference==
Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 3. Structure activity relationships at C3(1,2)., Yue EW, Higley CA, DiMeo SV, Carini DJ, Nugiel DA, Benware C, Benfield PA, Burton CR, Cox S, Grafstrom RH, Sharp DM, Sisk LM, Boylan JF, Muckelbauer JK, Smallwood AM, Chen H, Chang CH, Seitz SP, Trainor GL, J Med Chem. 2002 Nov 21;45(24):5233-48. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12431051 12431051]
Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 3. Structure activity relationships at C3(1,2)., Yue EW, Higley CA, DiMeo SV, Carini DJ, Nugiel DA, Benware C, Benfield PA, Burton CR, Cox S, Grafstrom RH, Sharp DM, Sisk LM, Boylan JF, Muckelbauer JK, Smallwood AM, Chen H, Chang CH, Seitz SP, Trainor GL, J Med Chem. 2002 Nov 21;45(24):5233-48. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12431051 12431051]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: protein kinase]]
[[Category: protein kinase]]


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