4n14: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n14 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n14 RCSB], [http://www.ebi.ac.uk/pdbsum/4n14 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n14 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n14 RCSB], [http://www.ebi.ac.uk/pdbsum/4n14 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/CDC20_HUMAN CDC20_HUMAN]] Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.<ref>PMID:9811605</ref> <ref>PMID:9734353</ref> <ref>PMID:9637688</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Luo, X | [[Category: Luo, X]] | ||
[[Category: Tian, W | [[Category: Tian, W]] | ||
[[Category: Yu, H | [[Category: Yu, H]] | ||
[[Category: Cell cycle]] | [[Category: Cell cycle]] | ||
[[Category: Cell cycle-cell cycle inhibitor complex]] | [[Category: Cell cycle-cell cycle inhibitor complex]] | ||
