3c6r: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3c6r]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2_thailand/puo-218/1980 Dengue virus 2 thailand/puo-218/1980]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C6R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3C6R FirstGlance]. <br> | <table><tr><td colspan='2'>[[3c6r]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2_thailand/puo-218/1980 Dengue virus 2 thailand/puo-218/1980]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C6R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3C6R FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c6r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3c6r RCSB], [http://www.ebi.ac.uk/pdbsum/3c6r PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c6r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3c6r RCSB], [http://www.ebi.ac.uk/pdbsum/3c6r PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/POLG_DEN2U POLG_DEN2U]] prM acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated (By similarity). Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity). Non-structural protein 1 is involved in virus replication and regulation of the innate immune response. Soluble and membrane-associated NS1 may activate human complement and induce host vascular leakage. This effect might explain the clinical manifestations of dengue hemorrhagic fever and dengue shock syndrome (By similarity). | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Dengue virus 2 thailand/puo-218/1980]] | [[Category: Dengue virus 2 thailand/puo-218/1980]] | ||
[[Category: Chen, J | [[Category: Chen, J]] | ||
[[Category: Chipman, P R | [[Category: Chipman, P R]] | ||
[[Category: Holdway, H A | [[Category: Holdway, H A]] | ||
[[Category: Kostyuchenko, V A | [[Category: Kostyuchenko, V A]] | ||
[[Category: Kuhn, R J | [[Category: Kuhn, R J]] | ||
[[Category: Li, L | [[Category: Li, L]] | ||
[[Category: Rossmann, M G | [[Category: Rossmann, M G]] | ||
[[Category: Yu, I | [[Category: Yu, I]] | ||
[[Category: Zhang, W | [[Category: Zhang, W]] | ||
[[Category: Capsid protein]] | [[Category: Capsid protein]] | ||
[[Category: Cleavage on pair of basic residue]] | [[Category: Cleavage on pair of basic residue]] | ||
