1ntl: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1ntl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NTL FirstGlance]. <br> | <table><tr><td colspan='2'>[[1ntl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NTL FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1qub|1qub]], [[1gkg|1gkg]], [[1ckl|1ckl]], [[1vvc|1vvc]], [[1igy|1igy]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1qub|1qub]], [[1gkg|1gkg]], [[1ckl|1ckl]], [[1vvc|1vvc]], [[1igy|1igy]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ntl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ntl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ntl RCSB], [http://www.ebi.ac.uk/pdbsum/1ntl PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ntl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ntl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ntl RCSB], [http://www.ebi.ac.uk/pdbsum/1ntl PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/CR1L_MOUSE CR1L_MOUSE]] Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Plays a crucial role in early embryonic development by maintaining fetomaternal tolerance. Also acts as a costimulatory factor for T-cells which favors IL-4 secretion.<ref>PMID:1730912</ref> <ref>PMID:7528766</ref> <ref>PMID:10779754</ref> <ref>PMID:10642554</ref> <ref>PMID:11986227</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Aslam, M | [[Category: Aslam, M]] | ||
[[Category: Guthridge, J M | [[Category: Guthridge, J M]] | ||
[[Category: Hack, B K | [[Category: Hack, B K]] | ||
[[Category: Holers, V M | [[Category: Holers, V M]] | ||
[[Category: Perkins, S J | [[Category: Perkins, S J]] | ||
[[Category: Quigg, R J | [[Category: Quigg, R J]] | ||
[[Category: Ccp]] | [[Category: Ccp]] | ||
[[Category: Complement]] | [[Category: Complement]] | ||
