4iyr: Difference between revisions
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==Crystal structure of full-length caspase-6 zymogen== | |||
=== | <StructureSection load='4iyr' size='340' side='right' caption='[[4iyr]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
== Structural highlights == | |||
==Function== | <table><tr><td colspan='2'>[[4iyr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IYR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IYR FirstGlance]. <br> | ||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3nr2|3nr2]], [[3v6l|3v6l]], [[3v6m|3v6m]], [[3od5|3od5]]</td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CASP6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-6 Caspase-6], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.59 3.4.22.59] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iyr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iyr RCSB], [http://www.ebi.ac.uk/pdbsum/4iyr PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. | [[http://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. | ||
== | ==See Also== | ||
[[ | *[[Caspase|Caspase]] | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Caspase-6]] | [[Category: Caspase-6]] | ||
[[Category: Cao, Q | [[Category: Human]] | ||
[[Category: Li, L F | [[Category: Cao, Q]] | ||
[[Category: Su, X D | [[Category: Li, L F]] | ||
[[Category: Wang, X J | [[Category: Su, X D]] | ||
[[Category: Wang, X J]] | |||
[[Category: Caspase fold]] | [[Category: Caspase fold]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Protease]] | [[Category: Protease]] | ||
Revision as of 03:19, 25 December 2014
Crystal structure of full-length caspase-6 zymogen
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