4jbk: Difference between revisions
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==Molecular basis for abrogation of activation of pro-inflammatory cytokines== | |||
<StructureSection load='4jbk' size='340' side='right' caption='[[4jbk]], [[Resolution|resolution]] 2.96Å' scene=''> | |||
== Structural highlights == | |||
==Function== | <table><tr><td colspan='2'>[[4jbk]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JBK FirstGlance]. <br> | ||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jbj|4jbj]], [[4jbm|4jbm]]</td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ifi202a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jbk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jbk RCSB], [http://www.ebi.ac.uk/pdbsum/4jbk PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/IFI2_MOUSE IFI2_MOUSE]] Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and may inhibit the activation of the AIM2 inflammasome, probably via association with AIM2.<ref>PMID:16670293</ref> <ref>PMID:19131592</ref> | [[http://www.uniprot.org/uniprot/IFI2_MOUSE IFI2_MOUSE]] Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and may inhibit the activation of the AIM2 inflammasome, probably via association with AIM2.<ref>PMID:16670293</ref> <ref>PMID:19131592</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Cheng, G | [[Category: Cheng, G]] | ||
[[Category: Crowley, C | [[Category: Crowley, C]] | ||
[[Category: Ding, W | [[Category: Ding, W]] | ||
[[Category: Hung, L W | [[Category: Hung, L W]] | ||
[[Category: Liu, Z J | [[Category: Liu, Z J]] | ||
[[Category: Ni, X | [[Category: Ni, X]] | ||
[[Category: Ru, H | [[Category: Ru, H]] | ||
[[Category: Shaw, N | [[Category: Shaw, N]] | ||
[[Category: Zhao, L | [[Category: Zhao, L]] | ||
[[Category: Dna]] | [[Category: Dna]] | ||
[[Category: Dna binding protein-dna complex]] | [[Category: Dna binding protein-dna complex]] | ||
[[Category: Ob fold]] | [[Category: Ob fold]] | ||
Revision as of 03:27, 25 December 2014
Molecular basis for abrogation of activation of pro-inflammatory cytokines
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