2bal: Difference between revisions

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[[Image:2bal.gif|left|200px]]<br /><applet load="2bal" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2bal.gif|left|200px]]
caption="2bal, resolution 2.10&Aring;" />
 
'''p38alpha MAP kinase bound to pyrazoloamine'''<br />
{{Structure
|PDB= 2bal |SIZE=350|CAPTION= <scene name='initialview01'>2bal</scene>, resolution 2.10&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=PQA:[5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL][3-(PIPERIDIN-4-YLOXY)PHENYL]METHANONE'>PQA</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1]
|GENE= MAPK14, CSBP, CSBP1, CSBP2, MXI2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''p38alpha MAP kinase bound to pyrazoloamine'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2BAL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=PQA:'>PQA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BAL OCA].  
2BAL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BAL OCA].  


==Reference==
==Reference==
Prevention of MKK6-dependent activation by binding to p38alpha MAP kinase., Sullivan JE, Holdgate GA, Campbell D, Timms D, Gerhardt S, Breed J, Breeze AL, Bermingham A, Pauptit RA, Norman RA, Embrey KJ, Read J, VanScyoc WS, Ward WH, Biochemistry. 2005 Dec 20;44(50):16475-90. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16342939 16342939]
Prevention of MKK6-dependent activation by binding to p38alpha MAP kinase., Sullivan JE, Holdgate GA, Campbell D, Timms D, Gerhardt S, Breed J, Breeze AL, Bermingham A, Pauptit RA, Norman RA, Embrey KJ, Read J, VanScyoc WS, Ward WH, Biochemistry. 2005 Dec 20;44(50):16475-90. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16342939 16342939]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: serine/threonine kinase]]
[[Category: serine/threonine kinase]]


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