2i46: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 6: | Line 6: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i46 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i46 RCSB], [http://www.ebi.ac.uk/pdbsum/2i46 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i46 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i46 RCSB], [http://www.ebi.ac.uk/pdbsum/2i46 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/ACD_HUMAN ACD_HUMAN]] Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity. Plays a role in shelterin complex assembly. May play a role in organogenesis.<ref>PMID:15181449</ref> <ref>PMID:16166375</ref> <ref>PMID:16880378</ref> <ref>PMID:20231318</ref> <ref>PMID:17237768</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 19: | Line 21: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Baciu, P | [[Category: Baciu, P]] | ||
[[Category: Cech, T R | [[Category: Cech, T R]] | ||
[[Category: Else, T | [[Category: Else, T]] | ||
[[Category: Hammer, G D | [[Category: Hammer, G D]] | ||
[[Category: Lei, M | [[Category: Lei, M]] | ||
[[Category: Podell, E R | [[Category: Podell, E R]] | ||
[[Category: Wang, F | [[Category: Wang, F]] | ||
[[Category: Yang, Y T | [[Category: Yang, Y T]] | ||
[[Category: Zaug, A J | [[Category: Zaug, A J]] | ||
[[Category: Ob fold]] | [[Category: Ob fold]] | ||
[[Category: Pot1 binding]] | [[Category: Pot1 binding]] | ||
[[Category: Protein binding]] | [[Category: Protein binding]] | ||
[[Category: Tpp1]] | [[Category: Tpp1]] | ||
