3w0u: Difference between revisions
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==human Glyoxalase I with an N-hydroxypyridone inhibitor== | |||
=== | <StructureSection load='3w0u' size='340' side='right' caption='[[3w0u]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | |||
==Function== | <table><tr><td colspan='2'>[[3w0u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bionectria_wenpingii Bionectria wenpingii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W0U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3W0U FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HPW:N-[3-(1-HYDROXY-6-OXO-4-PHENYL-1,6-DIHYDRO-PYRIDIN-2-YL)-5-METHANESULFONYLAMINO-PHENYL]-METHANESULFONAMIDE'>HPW</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3vw9|3vw9]], [[3w0t|3w0t]]</td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GLO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=466134 Bionectria wenpingii])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lactoylglutathione_lyase Lactoylglutathione lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.4.1.5 4.4.1.5] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w0u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3w0u RCSB], [http://www.ebi.ac.uk/pdbsum/3w0u PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/LGUL_HUMAN LGUL_HUMAN]] Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B.<ref>PMID:19199007</ref> | [[http://www.uniprot.org/uniprot/LGUL_HUMAN LGUL_HUMAN]] Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B.<ref>PMID:19199007</ref> | ||
== References == | |||
== | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
<references | |||
[[Category: Bionectria wenpingii]] | [[Category: Bionectria wenpingii]] | ||
[[Category: Lactoylglutathione lyase]] | [[Category: Lactoylglutathione lyase]] | ||
[[Category: Fukami, T A | [[Category: Fukami, T A]] | ||
[[Category: Irie, M | [[Category: Irie, M]] | ||
[[Category: Matsuura, T | [[Category: Matsuura, T]] | ||
[[Category: Glyoxalase]] | [[Category: Glyoxalase]] | ||
[[Category: Lyase-lyase inhibitor complex]] | [[Category: Lyase-lyase inhibitor complex]] | ||
