2be6: Difference between revisions

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[[Image:2be6.gif|left|200px]]<br /><applet load="2be6" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2be6.gif|left|200px]]
caption="2be6, resolution 2.000&Aring;" />
 
'''2.0 A crystal structure of the CaV1.2 IQ domain-Ca/CaM complex'''<br />
{{Structure
|PDB= 2be6 |SIZE=350|CAPTION= <scene name='initialview01'>2be6</scene>, resolution 2.000&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=NI:NICKEL (II) ION'>NI</scene>
|ACTIVITY=
|GENE= CALM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''2.0 A crystal structure of the CaV1.2 IQ domain-Ca/CaM complex'''
 


==Overview==
==Overview==
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==Disease==
==Disease==
Known diseases associated with this structure: Timothy syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=114205 114205]]
Known diseases associated with this structure: Brugada syndrome 3 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=114205 114205]], Timothy syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=114205 114205]]


==About this Structure==
==About this Structure==
2BE6 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=NI:'>NI</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BE6 OCA].  
2BE6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BE6 OCA].  


==Reference==
==Reference==
Insights into voltage-gated calcium channel regulation from the structure of the CaV1.2 IQ domain-Ca2+/calmodulin complex., Van Petegem F, Chatelain FC, Minor DL Jr, Nat Struct Mol Biol. 2005 Dec;12(12):1108-15. Epub 2005 Nov 20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16299511 16299511]
Insights into voltage-gated calcium channel regulation from the structure of the CaV1.2 IQ domain-Ca2+/calmodulin complex., Van Petegem F, Chatelain FC, Minor DL Jr, Nat Struct Mol Biol. 2005 Dec;12(12):1108-15. Epub 2005 Nov 20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16299511 16299511]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: voltage-gated]]
[[Category: voltage-gated]]


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