1qdp: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1qdp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atrax_robustus Atrax robustus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QDP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QDP FirstGlance]. <br> | <table><tr><td colspan='2'>[[1qdp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atrax_robustus Atrax robustus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QDP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QDP FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qdp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qdp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qdp RCSB], [http://www.ebi.ac.uk/pdbsum/1qdp PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qdp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qdp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qdp RCSB], [http://www.ebi.ac.uk/pdbsum/1qdp PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/TXDT1_ATRRO TXDT1_ATRRO]] Inhibits tetrodotoxin-sensitive voltage-gated sodium channels (Nav) by binding to site 3. It slows the inactivation, causes a prolongation of action potential duration resulting in repetitive firing in autonomic and motor nerve fibers. Does not depolarize the resting potential. Does not affect tetrodotoxin-resistant sodium channels. This lethal neurotoxin is active on both insect and mammalian voltage-gated sodium channels.<ref>PMID:2728033</ref> <ref>PMID:14596608</ref> <ref>PMID:9845331</ref> <ref>PMID:9560455</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 28: | Line 30: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Atrax robustus]] | [[Category: Atrax robustus]] | ||
[[Category: Alewood, D | [[Category: Alewood, D]] | ||
[[Category: Alewood, P F | [[Category: Alewood, P F]] | ||
[[Category: Norton, R S | [[Category: Norton, R S]] | ||
[[Category: Pallaghy, P K | [[Category: Pallaghy, P K]] | ||
[[Category: Cystine knot]] | [[Category: Cystine knot]] | ||
[[Category: Funnel web spider]] | [[Category: Funnel web spider]] | ||
