2bml: Difference between revisions

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[[Image:2bml.jpg|left|200px]]<br /><applet load="2bml" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2bml.jpg|left|200px]]
caption="2bml, resolution 2.60&Aring;" />
 
'''OFLOXACIN-LIKE ANTIBIOTICS INHIBIT PNEUMOCOCCAL CELL WALL DEGRADING VIRULENCE FACTORS'''<br />
{{Structure
|PDB= 2bml |SIZE=350|CAPTION= <scene name='initialview01'>2bml</scene>, resolution 2.60&Aring;
|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+B'>AC1</scene>
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=XED:DEXTROFLOXACINE'>XED</scene> and <scene name='pdbligand=PG4:TETRAETHYLENE GLYCOL'>PG4</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/N-acetylmuramoyl-L-alanine_amidase N-acetylmuramoyl-L-alanine amidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.28 3.5.1.28]
|GENE=
}}
 
'''OFLOXACIN-LIKE ANTIBIOTICS INHIBIT PNEUMOCOCCAL CELL WALL DEGRADING VIRULENCE FACTORS'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2BML is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=TRS:'>TRS</scene>, <scene name='pdbligand=P6G:'>P6G</scene>, <scene name='pdbligand=XED:'>XED</scene> and <scene name='pdbligand=PG4:'>PG4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/N-acetylmuramoyl-L-alanine_amidase N-acetylmuramoyl-L-alanine amidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.28 3.5.1.28] Known structural/functional Site: <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+B'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BML OCA].  
2BML is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BML OCA].  


==Reference==
==Reference==
Ofloxacin-like antibiotics inhibit pneumococcal cell wall-degrading virulence factors., Fernandez-Tornero C, Garcia E, de Pascual-Teresa B, Lopez R, Gimenez-Gallego G, Romero A, J Biol Chem. 2005 May 20;280(20):19948-57. Epub 2005 Mar 15. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15769740 15769740]
Ofloxacin-like antibiotics inhibit pneumococcal cell wall-degrading virulence factors., Fernandez-Tornero C, Garcia E, de Pascual-Teresa B, Lopez R, Gimenez-Gallego G, Romero A, J Biol Chem. 2005 May 20;280(20):19948-57. Epub 2005 Mar 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15769740 15769740]
[[Category: N-acetylmuramoyl-L-alanine amidase]]
[[Category: N-acetylmuramoyl-L-alanine amidase]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: cell wall attachment]]
[[Category: cell wall attachment]]
[[Category: choline-binding domain]]
[[Category: choline-binding domain]]
[[Category: ofloxacin-like antibiotics]]
[[Category: ofloxacin-like antibiotic]]


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