2bnl: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:2bnl.gif|left|200px]] | [[Image:2bnl.gif|left|200px]] | ||
'''THE STRUCTURE OF THE N-TERMINAL DOMAIN OF RSBR''' | {{Structure | ||
|PDB= 2bnl |SIZE=350|CAPTION= <scene name='initialview01'>2bnl</scene>, resolution 2.00Å | |||
|SITE= <scene name='pdbsite=AC1:Na+Binding+Site+For+Chain+F'>AC1</scene> | |||
|LIGAND= <scene name='pdbligand=NA:SODIUM ION'>NA</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''THE STRUCTURE OF THE N-TERMINAL DOMAIN OF RSBR''' | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
2BNL is a [ | 2BNL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BNL OCA]. | ||
==Reference== | ==Reference== | ||
Structure of a nonheme globin in environmental stress signaling., Murray JW, Delumeau O, Lewis RJ, Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17320-5. Epub 2005 Nov 21. PMID:[http:// | Structure of a nonheme globin in environmental stress signaling., Murray JW, Delumeau O, Lewis RJ, Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17320-5. Epub 2005 Nov 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16301540 16301540] | ||
[[Category: Bacillus subtilis]] | [[Category: Bacillus subtilis]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 20: | Line 29: | ||
[[Category: stress response]] | [[Category: stress response]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:04:13 2008'' | ||
Revision as of 14:04, 20 March 2008
| |||||||||||||
| 2bnl, resolution 2.00Å | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sites: | AC1 | ||||||||||||
| Ligands: | NA | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
THE STRUCTURE OF THE N-TERMINAL DOMAIN OF RSBR
Overview
RsbR is a regulator of sigma(B), the RNA polymerase sigma factor subunit responsible for transcribing the general stress response genes when environmental stress is imposed on Bacillus subtilis. The C-terminal domain of RsbR and its paralogues is a substrate for the kinase function of another sigma(B) regulator, RsbT, but the amino acid sequence of the N-terminal domain of RsbR does not reveal any obvious biochemical function. RsbR, its paralogues, and other regulators of sigma(B), including RsbS and RsbT, form large signaling complexes, called stressosomes. We have determined and present here the crystal structure of the N-terminal domain of RsbR. Unexpectedly, this structure belongs to the globin fold superfamily, but there is no bound cofactor. The globin domain from globin-coupled sensory systems replaces the N-terminal domain of RsbR in some bacteria, indicating a common genetic ancestry for RsbR and the globin family. We suggest that the globin fold has been "recycled" in RsbR and that one more activity can be included in the repertoire of globin functions, namely the ability to bind signaling macromolecules such as RsbT.
About this Structure
2BNL is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.
Reference
Structure of a nonheme globin in environmental stress signaling., Murray JW, Delumeau O, Lewis RJ, Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17320-5. Epub 2005 Nov 21. PMID:16301540
Page seeded by OCA on Thu Mar 20 16:04:13 2008
