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[[Image:3vej.png|left|200px]]
==Crystal structure of the Get5 carboxyl domain from S. cerevisiae==
<StructureSection load='3vej' size='340' side='right' caption='[[3vej]], [[Resolution|resolution]] 1.23&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3vej]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VEJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VEJ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2lnz|2lnz]], [[2lo0|2lo0]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GET5, MDY2, TMA24, YOL111C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vej OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vej RCSB], [http://www.ebi.ac.uk/pdbsum/3vej PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/MDY2_YEAST MDY2_YEAST]] Required for efficient mating. Involved in the production of alpha-factor, the KAR9 and TUB1 location to the shmoo tip and nuclear migration into pheromone-induced shmoos.<ref>PMID:10514570</ref> <ref>PMID:16390866</ref> 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Tail-anchored trans-membrane proteins are targeted to membranes post-translationally. The proteins Get4 and Get5 form an obligate complex that catalyzes the transfer of tail-anchored proteins destined to the endoplasmic reticulum from Sgt2 to the cytosolic targeting factor Get3. Get5 forms a homodimer mediated by its carboxyl domain. We show here that a conserved motif exists within the carboxyl domain. A high resolution crystal structure and solution NMR structures of this motif reveal a novel and stable helical dimerization domain. We additionally determined a solution NMR structure of a divergent fungal homolog, and comparison of these structures allows annotation of specific stabilizing interactions. Using solution x-ray scattering and the structures of all folded domains, we present a model of the full-length Get4/Get5 complex.


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Get5 Carboxyl-terminal Domain Is a Novel Dimerization Motif That Tethers an Extended Get4/Get5 Complex.,Chartron JW, Vandervelde DG, Rao M, Clemons WM Jr J Biol Chem. 2012 Mar 9;287(11):8310-7. Epub 2012 Jan 17. PMID:22262836<ref>PMID:22262836</ref>
The line below this paragraph, containing "STRUCTURE_3vej", creates the "Structure Box" on the page.
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{{STRUCTURE_3vej|  PDB=3vej  |  SCENE=  }}


===Crystal structure of the Get5 carboxyl domain from S. cerevisiae===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
 
== References ==
<!--
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_22262836}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_22262836}}
 
==About this Structure==
[[3vej]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VEJ OCA].
 
==Reference==
<ref group="xtra">PMID:022262836</ref><references group="xtra"/>
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Chartron, J W.]]
[[Category: Chartron, J W]]
[[Category: Clemons, W M.]]
[[Category: Clemons, W M]]
[[Category: Rao, M.]]
[[Category: Rao, M]]
[[Category: Vandervelde, D G.]]
[[Category: Vandervelde, D G]]
[[Category: Alpha helical]]
[[Category: Alpha helical]]
[[Category: Dimerization]]
[[Category: Dimerization]]
[[Category: Homodimerization]]
[[Category: Homodimerization]]
[[Category: Protein binding]]
[[Category: Protein binding]]

Revision as of 05:11, 25 December 2014

Crystal structure of the Get5 carboxyl domain from S. cerevisiae

3vej, resolution 1.23Å

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