2bre: Difference between revisions

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[[Image:2bre.gif|left|200px]]<br /><applet load="2bre" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2bre.gif|left|200px]]
caption="2bre, resolution 2.0&Aring;" />
 
'''STRUCTURE OF A HSP90 INHIBITOR BOUND TO THE N-TERMINUS OF YEAST HSP90.'''<br />
{{Structure
|PDB= 2bre |SIZE=350|CAPTION= <scene name='initialview01'>2bre</scene>, resolution 2.0&Aring;
|SITE= <scene name='pdbsite=AC1:Kj2+Binding+Site+For+Chain+B'>AC1</scene>
|LIGAND= <scene name='pdbligand=KJ2:4-{4-[4-(3-AMINOPROPOXY)PHENYL]-1H-PYRAZOL-5-YL}-6-CHLOROBENZENE-1,3-DIOL'>KJ2</scene>
|ACTIVITY=
|GENE=
}}
 
'''STRUCTURE OF A HSP90 INHIBITOR BOUND TO THE N-TERMINUS OF YEAST HSP90.'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2BRE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with <scene name='pdbligand=KJ2:'>KJ2</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Kj2+Binding+Site+For+Chain+B'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BRE OCA].  
2BRE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BRE OCA].  


==Reference==
==Reference==
The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors., Cheung KM, Matthews TP, James K, Rowlands MG, Boxall KJ, Sharp SY, Maloney A, Roe SM, Prodromou C, Pearl LH, Aherne GW, McDonald E, Workman P, Bioorg Med Chem Lett. 2005 Jul 15;15(14):3338-43. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15955698 15955698]
The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors., Cheung KM, Matthews TP, James K, Rowlands MG, Boxall KJ, Sharp SY, Maloney A, Roe SM, Prodromou C, Pearl LH, Aherne GW, McDonald E, Workman P, Bioorg Med Chem Lett. 2005 Jul 15;15(14):3338-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15955698 15955698]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: multigene family]]
[[Category: multigene family]]


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