4e5y: Difference between revisions
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==Structure of human FX protein, the key enzyme in the biosynthesis of GDP-L-fucose== | |||
<StructureSection load='4e5y' size='340' side='right' caption='[[4e5y]], [[Resolution|resolution]] 2.37Å' scene=''> | |||
== Structural highlights == | |||
==Function== | <table><tr><td colspan='2'>[[4e5y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E5Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E5Y FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TSTA3, SDR4E1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/GDP-L-fucose_synthase GDP-L-fucose synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.271 1.1.1.271] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e5y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4e5y RCSB], [http://www.ebi.ac.uk/pdbsum/4e5y PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/FCL_HUMAN FCL_HUMAN]] Two step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. | [[http://www.uniprot.org/uniprot/FCL_HUMAN FCL_HUMAN]] Two step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: GDP-L-fucose synthase]] | [[Category: GDP-L-fucose synthase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: He, J H | [[Category: He, J H]] | ||
[[Category: Zhou, H | [[Category: Zhou, H]] | ||
[[Category: Biosynthesis]] | [[Category: Biosynthesis]] | ||
[[Category: Gdp-l-fucose]] | [[Category: Gdp-l-fucose]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
Revision as of 05:38, 25 December 2014
Structure of human FX protein, the key enzyme in the biosynthesis of GDP-L-fucose
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