2bt4: Difference between revisions

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[[Image:2bt4.gif|left|200px]]<br /><applet load="2bt4" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2bt4.gif|left|200px]]
caption="2bt4, resolution 1.70&Aring;" />
 
'''TYPE II DEHYDROQUINASE INHIBITOR COMPLEX'''<br />
{{Structure
|PDB= 2bt4 |SIZE=350|CAPTION= <scene name='initialview01'>2bt4</scene>, resolution 1.70&Aring;
|SITE= <scene name='pdbsite=AC1:Trs+Binding+Site+For+Chain+L'>AC1</scene>
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=CA2:(1S,3R,4R,5S)-1,3,4-TRIHYDROXY-5-(3-PHENOXYPROPYL)CYCLOHEXANECARBOXYLIC+ACID'>CA2</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10]
|GENE=
}}
 
'''TYPE II DEHYDROQUINASE INHIBITOR COMPLEX'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2BT4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor] with <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=CA2:'>CA2</scene>, <scene name='pdbligand=TRS:'>TRS</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] Known structural/functional Site: <scene name='pdbsite=AC1:Trs+Binding+Site+For+Chain+L'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BT4 OCA].  
2BT4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BT4 OCA].  


==Reference==
==Reference==
Rational design of new bifunctional inhibitors of type II dehydroquinase., Toscano MD, Stewart KA, Coggins JR, Lapthorn AJ, Abell C, Org Biomol Chem. 2005 Sep 7;3(17):3102-4. Epub 2005 Aug 1. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16106291 16106291]
Rational design of new bifunctional inhibitors of type II dehydroquinase., Toscano MD, Stewart KA, Coggins JR, Lapthorn AJ, Abell C, Org Biomol Chem. 2005 Sep 7;3(17):3102-4. Epub 2005 Aug 1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16106291 16106291]
[[Category: 3-dehydroquinate dehydratase]]
[[Category: 3-dehydroquinate dehydratase]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: shikimate pathway]]
[[Category: shikimate pathway]]


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