4qin: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4qin]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QIN FirstGlance]. <br> | <table><tr><td colspan='2'>[[4qin]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QIN FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SG8:3-CHLORO-4,7-DIFLUORO-N-[TRANS-4-(METHYLAMINO)CYCLOHEXYL]-N-[3-(PYRIDIN-4-YL)BENZYL]-1-BENZOTHIOPHENE-2-CARBOXAMIDE'>SG8</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SG8:3-CHLORO-4,7-DIFLUORO-N-[TRANS-4-(METHYLAMINO)CYCLOHEXYL]-N-[3-(PYRIDIN-4-YL)BENZYL]-1-BENZOTHIOPHENE-2-CARBOXAMIDE'>SG8</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4o9r|4o9r]], [[4qim|4qim]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4o9r|4o9r]], [[4qim|4qim]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qin OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qin RCSB], [http://www.ebi.ac.uk/pdbsum/4qin PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qin OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qin RCSB], [http://www.ebi.ac.uk/pdbsum/4qin PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/SMO_HUMAN SMO_HUMAN]] G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.<ref>PMID:19592253</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Caron, M G | [[Category: Caron, M G]] | ||
[[Category: Cherezov, V | [[Category: Cherezov, V]] | ||
[[Category: Evron, T | [[Category: Evron, T]] | ||
[[Category: GPCR, GPCR Network | [[Category: GPCR, GPCR Network]] | ||
[[Category: Han, G W | [[Category: Han, G W]] | ||
[[Category: Huang, X P | [[Category: Huang, X P]] | ||
[[Category: Hufeisen, S J | [[Category: Hufeisen, S J]] | ||
[[Category: Katritch, V | [[Category: Katritch, V]] | ||
[[Category: Mangano, T J | [[Category: Mangano, T J]] | ||
[[Category: Roth, B L | [[Category: Roth, B L]] | ||
[[Category: Stevens, R C | [[Category: Stevens, R C]] | ||
[[Category: Urban, D J | [[Category: Urban, D J]] | ||
[[Category: Vardy, E | [[Category: Vardy, E]] | ||
[[Category: Wang, C | [[Category: Wang, C]] | ||
[[Category: Wu, H | [[Category: Wu, H]] | ||
[[Category: Agonist]] | [[Category: Agonist]] | ||
[[Category: Gpcr]] | [[Category: Gpcr]] | ||
