4o1z: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 2: | Line 2: | ||
<StructureSection load='4o1z' size='340' side='right' caption='[[4o1z]], [[Resolution|resolution]] 2.40Å' scene=''> | <StructureSection load='4o1z' size='340' side='right' caption='[[4o1z]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4o1z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O1Z OCA]. <br> | <table><tr><td colspan='2'>[[4o1z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O1Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O1Z FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MXM:4-HYDROXY-2-METHYL-N-(5-METHYL-1,3-THIAZOL-2-YL)-2H-1,2-BENZOTHIAZINE-3-CARBOXAMIDE+1,1-DIOXIDE'>MXM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MXM:4-HYDROXY-2-METHYL-N-(5-METHYL-1,3-THIAZOL-2-YL)-2H-1,2-BENZOTHIAZINE-3-CARBOXAMIDE+1,1-DIOXIDE'>MXM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4m11|4m11]], [[1diy|1diy]], [[1q4g|1q4g]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4m11|4m11]], [[1diy|1diy]], [[1q4g|1q4g]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o1z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o1z RCSB], [http://www.ebi.ac.uk/pdbsum/4o1z PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o1z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o1z RCSB], [http://www.ebi.ac.uk/pdbsum/4o1z PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/PGH1_SHEEP PGH1_SHEEP]] May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells. | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 14: | Line 16: | ||
Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network.,Xu S, Hermanson DJ, Banerjee S, Ghebreselasie K, Clayton GM, Garavito RM, Marnett LJ J Biol Chem. 2014 Jan 14. PMID:24425867<ref>PMID:24425867</ref> | Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network.,Xu S, Hermanson DJ, Banerjee S, Ghebreselasie K, Clayton GM, Garavito RM, Marnett LJ J Biol Chem. 2014 Jan 14. PMID:24425867<ref>PMID:24425867</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
== References == | == References == | ||
| Line 22: | Line 24: | ||
[[Category: Ovis aries]] | [[Category: Ovis aries]] | ||
[[Category: Prostaglandin-endoperoxide synthase]] | [[Category: Prostaglandin-endoperoxide synthase]] | ||
[[Category: Banerjee, S | [[Category: Banerjee, S]] | ||
[[Category: Clayton, G M | [[Category: Clayton, G M]] | ||
[[Category: Garavito, R M | [[Category: Garavito, R M]] | ||
[[Category: Ghebreselasie, K | [[Category: Ghebreselasie, K]] | ||
[[Category: Hermanson, D J | [[Category: Hermanson, D J]] | ||
[[Category: Marnett, L J | [[Category: Marnett, L J]] | ||
[[Category: Xu, S | [[Category: Xu, S]] | ||
[[Category: Dioxygenase]] | [[Category: Dioxygenase]] | ||
[[Category: Glycosylation]] | [[Category: Glycosylation]] | ||
