3shg: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3shg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bartonella_schoenbuchensis_r1 Bartonella schoenbuchensis r1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SHG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SHG FirstGlance]. <br> | <table><tr><td colspan='2'>[[3shg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bartonella_schoenbuchensis_r1 Bartonella schoenbuchensis r1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SHG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SHG FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jk8|2jk8]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jk8|2jk8]]</td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">B11C_100026 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=687861 Bartonella schoenbuchensis R1]), B11C_100027 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=687861 Bartonella schoenbuchensis R1])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">B11C_100026 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=687861 Bartonella schoenbuchensis R1]), B11C_100027 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=687861 Bartonella schoenbuchensis R1])</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3shg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3shg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3shg RCSB], [http://www.ebi.ac.uk/pdbsum/3shg PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3shg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3shg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3shg RCSB], [http://www.ebi.ac.uk/pdbsum/3shg PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/E6Z0R3_9RHIZ E6Z0R3_9RHIZ]] Toxic component of a toxin-antitoxin (TA) module VbhT-VbhA. Adenylyltransferase involved in virulence by mediating the addition of adenosine 5'-monophosphate (AMP) to specific residue of host GTPases. The resulting AMPylation affects GTPases, impairing actin assembly in infected cells. [[http://www.uniprot.org/uniprot/E6Z0R4_9RHIZ E6Z0R4_9RHIZ]] Antitoxin component of a toxin-antitoxin (TA) module VbhT-VbhA. Acts by inhibiting the adenylyltransferase activity of VbhT; competes with ATP-binding and prevents productive ATP-binding to VbhT. | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins.,Engel P, Goepfert A, Stanger FV, Harms A, Schmidt A, Schirmer T, Dehio C Nature. 2012 Jan 22;482(7383):107-10. doi: 10.1038/nature10729. PMID:22266942<ref>PMID:22266942</ref> | Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins.,Engel P, Goepfert A, Stanger FV, Harms A, Schmidt A, Schirmer T, Dehio C Nature. 2012 Jan 22;482(7383):107-10. doi: 10.1038/nature10729. PMID:22266942<ref>PMID:22266942</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Bartonella schoenbuchensis r1]] | [[Category: Bartonella schoenbuchensis r1]] | ||
[[Category: Goepfert, A | [[Category: Goepfert, A]] | ||
[[Category: Schirmer, T | [[Category: Schirmer, T]] | ||
[[Category: Adenylylation]] | [[Category: Adenylylation]] | ||
[[Category: Amp transfer]] | [[Category: Amp transfer]] | ||
