2c4w: Difference between revisions

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[[Image:2c4w.gif|left|200px]]<br /><applet load="2c4w" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2c4w.gif|left|200px]]
caption="2c4w, resolution 1.55&Aring;" />
 
'''TYPE II DEHYDROQUINASE FROM H. PYLORI IN COMPLEX WITH AH9095'''<br />
{{Structure
|PDB= 2c4w |SIZE=350|CAPTION= <scene name='initialview01'>2c4w</scene>, resolution 1.55&Aring;
|SITE= <scene name='pdbsite=AC1:Imd+Binding+Site+For+Chain+A'>AC1</scene>
|LIGAND= <scene name='pdbligand=GAJ:N-TETRAZOL-5-YL+9-OXO-9H-XANTHENE-2+SULPHONAMIDE'>GAJ</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10]
|GENE=
}}
 
'''TYPE II DEHYDROQUINASE FROM H. PYLORI IN COMPLEX WITH AH9095'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2C4W is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori] with <scene name='pdbligand=GAJ:'>GAJ</scene>, <scene name='pdbligand=IMD:'>IMD</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] Known structural/functional Site: <scene name='pdbsite=AC1:Imd+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C4W OCA].  
2C4W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C4W OCA].  


==Reference==
==Reference==
Crystal structures of Helicobacter pylori type II dehydroquinase inhibitor complexes: new directions for inhibitor design., Robinson DA, Stewart KA, Price NC, Chalk PA, Coggins JR, Lapthorn AJ, J Med Chem. 2006 Feb 23;49(4):1282-90. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16480265 16480265]
Crystal structures of Helicobacter pylori type II dehydroquinase inhibitor complexes: new directions for inhibitor design., Robinson DA, Stewart KA, Price NC, Chalk PA, Coggins JR, Lapthorn AJ, J Med Chem. 2006 Feb 23;49(4):1282-90. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16480265 16480265]
[[Category: 3-dehydroquinate dehydratase]]
[[Category: 3-dehydroquinate dehydratase]]
[[Category: Helicobacter pylori]]
[[Category: Helicobacter pylori]]
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[[Category: sulphonamide]]
[[Category: sulphonamide]]


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