2adc: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2adc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ADC FirstGlance]. <br> | <table><tr><td colspan='2'>[[2adc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ADC FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ad9|2ad9]], [[2adb|2adb]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ad9|2ad9]], [[2adb|2adb]]</td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTB-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTB-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2adc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2adc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2adc RCSB], [http://www.ebi.ac.uk/pdbsum/2adc PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2adc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2adc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2adc RCSB], [http://www.ebi.ac.uk/pdbsum/2adc PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/PTBP1_HUMAN PTBP1_HUMAN]] Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10.<ref>PMID:11003644</ref> <ref>PMID:15009664</ref> <ref>PMID:16260624</ref> <ref>PMID:21518792</ref> <ref>PMID:16179478</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Allain, F H.T | [[Category: Allain, F H.T]] | ||
[[Category: Auweter, S D | [[Category: Auweter, S D]] | ||
[[Category: Black, D L | [[Category: Black, D L]] | ||
[[Category: Erat, M | [[Category: Erat, M]] | ||
[[Category: Hargous, Y | [[Category: Hargous, Y]] | ||
[[Category: Henning, A | [[Category: Henning, A]] | ||
[[Category: Oberstrass, F C | [[Category: Oberstrass, F C]] | ||
[[Category: Pitsch, S | [[Category: Pitsch, S]] | ||
[[Category: Reymond, L | [[Category: Reymond, L]] | ||
[[Category: Wenter, P | [[Category: Wenter, P]] | ||
[[Category: Protein-rna complex]] | [[Category: Protein-rna complex]] | ||
[[Category: Rbd]] | [[Category: Rbd]] | ||
[[Category: Rna binding protein-rna complex]] | [[Category: Rna binding protein-rna complex]] | ||
[[Category: Rrm]] | [[Category: Rrm]] | ||
