2he7: Difference between revisions

Revision as of 07:44, 25 December 2014

FERM domain of EPB41L3 (DAL-1)

Structural highlights

2he7 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	EPB41L3 (Homo sapiens)
Resources:	FirstGlance, OCA, RCSB, PDBsum

Function

[E41L3_HUMAN] Critical growth regulator in the pathogenesis of meningiomas.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Perturbed cell-adhesion mechanisms are crucial for tumor invasion and metastasis. A cell-adhesion protein, Tumor Suppressor in Lung Cancer 1 (TSLC1), is inactivated in a majority of metastatic cancers. DAL-1 (differentially expressed in adenocarcinoma of the lung protein), another tumor suppressor, binds through its FERM domain to the TSLC1 C-terminal, 4.1 glycophorin C-like, cytoplasmic domain. However, the molecular basis for this interaction is unknown. Here, we describe the crystal structure of a complex between the DAL-1 FERM domain and a portion of the TSLC1 cytoplasmic domain. DAL-1 binds to TSLC1 through conserved residues in a well-defined hydrophobic pocket in the DAL-1 FERM domain's structural C-lobe. From the crystal structure, it is apparent that Tyr406 and Thr408 in the TSLC1 cytoplasmic domain form the most important interactions with DAL-1 and this was also confirmed by surface plasmon resonance studies. Our results refute earlier exon deletion experiments that indicated that glycophorin-C interacts with the alpha-lobe of 4.1 FERM domains.

Structural basis of tumor suppressor in lung cancer 1 (TSLC1) binding to differentially expressed in adenocarcinoma of the lung (DAL-1/4.1B).,Busam RD, Thorsell AG, Flores A, Hammarstrom M, Persson C, Obrink B, Hallberg BM J Biol Chem. 2010 Dec 3. PMID:21131357^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Busam RD, Thorsell AG, Flores A, Hammarstrom M, Persson C, Obrink B, Hallberg BM. Structural basis of tumor suppressor in lung cancer 1 (TSLC1) binding to differentially expressed in adenocarcinoma of the lung (DAL-1/4.1B). J Biol Chem. 2010 Dec 3. PMID:21131357 doi:10.1074/jbc.M110.174011

Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Busam RD, Thorsell AG, Flores A, Hammarstrom M, Persson C, Obrink B, Hallberg BM. Structural basis of tumor suppressor in lung cancer 1 (TSLC1) binding to differentially expressed in adenocarcinoma of the lung (DAL-1/4.1B). J Biol Chem. 2010 Dec 3. PMID:21131357 doi:10.1074/jbc.M110.174011

[1]

@@ Line 3: / Line 3: @@
 == Structural highlights ==
 <table><tr><td colspan='2'>[[2he7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HE7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HE7 FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EPB41L3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EPB41L3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2he7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2he7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2he7 RCSB], [http://www.ebi.ac.uk/pdbsum/2he7 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2he7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2he7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2he7 RCSB], [http://www.ebi.ac.uk/pdbsum/2he7 PDBsum]</span></td></tr>
-<table>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/E41L3_HUMAN E41L3_HUMAN]] Critical growth regulator in the pathogenesis of meningiomas.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 29: / Line 31: @@
 </StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Arrowsmith, C.]]
+[[Category: Arrowsmith, C]]
-[[Category: Berglund, H.]]
+[[Category: Berglund, H]]
-[[Category: Busam, R D.]]
+[[Category: Busam, R D]]
-[[Category: Collins, R.]]
+[[Category: Collins, R]]
-[[Category: Edwards, A.]]
+[[Category: Edwards, A]]
-[[Category: Ehn, M.]]
+[[Category: Ehn, M]]
-[[Category: Flodin, S.]]
+[[Category: Flodin, S]]
-[[Category: Flores, A.]]
+[[Category: Flores, A]]
-[[Category: Graslund, S.]]
+[[Category: Graslund, S]]
-[[Category: Hallberg, B M.]]
+[[Category: Hallberg, B M]]
-[[Category: Hammarstrom, M.]]
+[[Category: Hammarstrom, M]]
-[[Category: Hogbom, M.]]
+[[Category: Hogbom, M]]
-[[Category: Johansson, I.]]
+[[Category: Johansson, I]]
-[[Category: Karlberg, T.]]
+[[Category: Karlberg, T]]
-[[Category: Kotenyova, T.]]
+[[Category: Kotenyova, T]]
-[[Category: Nilsson-ehle, P.]]
+[[Category: Nilsson-ehle, P]]
-[[Category: Nilvebrandt, J.]]
+[[Category: Nilvebrandt, J]]
-[[Category: Norberg, P.]]
+[[Category: Norberg, P]]
-[[Category: Nordlund, P.]]
+[[Category: Nordlund, P]]
-[[Category: Nyman, T.]]
+[[Category: Nyman, T]]
-[[Category: Ogg, D.]]
+[[Category: Ogg, D]]
-[[Category: Persson, C.]]
+[[Category: Persson, C]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Structural genomic]]
-[[Category: Sagemark, J.]]
+[[Category: Sagemark, J]]
-[[Category: Schiavone, L H.]]
+[[Category: Schiavone, L H]]
-[[Category: Stenmark, P.]]
+[[Category: Stenmark, P]]
-[[Category: Sundstrom, M.]]
+[[Category: Sundstrom, M]]
-[[Category: Thorsell, A G.]]
+[[Category: Thorsell, A G]]
-[[Category: Uppenberg, J.]]
+[[Category: Uppenberg, J]]
-[[Category: Weigelt, J.]]
+[[Category: Weigelt, J]]
-[[Category: Berg, S Van den.]]
+[[Category: Berg, S Van den]]
 [[Category: Cell adhesion]]
 [[Category: Dal-1]]
@@ Line 65: / Line 67: @@
 [[Category: Ferm domain]]
 [[Category: Sgc]]
-[[Category: Structural genomic]]
-[[Category: Structural genomics consortium]]

2he7: Difference between revisions

Revision as of 07:44, 25 December 2014

FERM domain of EPB41L3 (DAL-1)

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

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