2ccj: Difference between revisions

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[[Image:2ccj.gif|left|200px]]<br /><applet load="2ccj" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2ccj.gif|left|200px]]
caption="2ccj, resolution 1.70&Aring;" />
 
'''CRYSTAL STRUCTURE OF S. AUREUS THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE'''<br />
{{Structure
|PDB= 2ccj |SIZE=350|CAPTION= <scene name='initialview01'>2ccj</scene>, resolution 1.70&Aring;
|SITE= <scene name='pdbsite=AC1:Egl+Binding+Site+For+Chain+B'>AC1</scene>
|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TMP:THYMIDINE-5'-PHOSPHATE'>TMP</scene> and <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9]
|GENE=
}}
 
'''CRYSTAL STRUCTURE OF S. AUREUS THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2CCJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus] with <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=TMP:'>TMP</scene> and <scene name='pdbligand=EDO:'>EDO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9] Known structural/functional Site: <scene name='pdbsite=AC1:Egl+Binding+Site+For+Chain+B'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCJ OCA].  
2CCJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCJ OCA].  


==Reference==
==Reference==
Structures of S. aureus thymidylate kinase reveal an atypical active site configuration and an intermediate conformational state upon substrate binding., Kotaka M, Dhaliwal B, Ren J, Nichols CE, Angell R, Lockyer M, Hawkins AR, Stammers DK, Protein Sci. 2006 Apr;15(4):774-84. Epub 2006 Mar 7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16522804 16522804]
Structures of S. aureus thymidylate kinase reveal an atypical active site configuration and an intermediate conformational state upon substrate binding., Kotaka M, Dhaliwal B, Ren J, Nichols CE, Angell R, Lockyer M, Hawkins AR, Stammers DK, Protein Sci. 2006 Apr;15(4):774-84. Epub 2006 Mar 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16522804 16522804]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: transferase]]
[[Category: transferase]]


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