2cd2: Difference between revisions

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[[Image:2cd2.jpg|left|200px]]<br /><applet load="2cd2" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2cd2.jpg|left|200px]]
caption="2cd2, resolution 1.900&Aring;" />
 
'''LIGAND INDUCED CONFORMATIONAL CHANGES IN THE CRYSTAL STRUCTURES OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE COMPLEXES WITH FOLATE AND NADP+'''<br />
{{Structure
|PDB= 2cd2 |SIZE=350|CAPTION= <scene name='initialview01'>2cd2</scene>, resolution 1.900&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene> and <scene name='pdbligand=FOL:FOLIC ACID'>FOL</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3]
|GENE=
}}
 
'''LIGAND INDUCED CONFORMATIONAL CHANGES IN THE CRYSTAL STRUCTURES OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE COMPLEXES WITH FOLATE AND NADP+'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2CD2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pneumocystis_carinii Pneumocystis carinii] with <scene name='pdbligand=NAP:'>NAP</scene> and <scene name='pdbligand=FOL:'>FOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CD2 OCA].  
2CD2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pneumocystis_carinii Pneumocystis carinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CD2 OCA].  


==Reference==
==Reference==
Ligand-induced conformational changes in the crystal structures of Pneumocystis carinii dihydrofolate reductase complexes with folate and NADP+., Cody V, Galitsky N, Rak D, Luft JR, Pangborn W, Queener SF, Biochemistry. 1999 Apr 6;38(14):4303-12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10194348 10194348]
Ligand-induced conformational changes in the crystal structures of Pneumocystis carinii dihydrofolate reductase complexes with folate and NADP+., Cody V, Galitsky N, Rak D, Luft JR, Pangborn W, Queener SF, Biochemistry. 1999 Apr 6;38(14):4303-12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10194348 10194348]
[[Category: Dihydrofolate reductase]]
[[Category: Dihydrofolate reductase]]
[[Category: Pneumocystis carinii]]
[[Category: Pneumocystis carinii]]
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[[Category: oxido-reductase]]
[[Category: oxido-reductase]]


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